Slavia Prague forward Peter Olayinka will lead the Super Eagles attack in Wednesday’s Group D clash against Guinea-Bissau.
Interim Head Coach Austine Eguavoen is set to ring the changes with a place in the second round already secured after wins against Egypt and Sudan.
Olayinka, who is yet to make an appearance for the Super Eagles at the 2021 Africa Cup of Nation in Cameroon will shoulder goal scoring responsibility against the Djurtus.
Omonia Nicosia goalkeeper Francis Uzoho will be the man behind the sticks, while Tyronne Ebuehi and Jamilu Collins will also make their first appearance in the competition.
Meanwhile, the Confederation of African Football has appointed Kenyan official Peter Waweru Kamaku as referee for Wednesday’s encounter.
The Match Commissioner will be Youssouf Guedi Guirreh from Djibouti.